HIF-1α Provokes Delayed Neutrophil Apoptosis by Decreasing 24P3 Expression and Intracellular Iron Content
نویسندگان
چکیده
منابع مشابه
HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation
Many human diseases are characterized by the development of tissue hypoxia. Hypoxia-inducible factor (HIF) is a transcription factor that regulates fundamental cellular processes in response to changes in oxygen concentration, such as angiogenesis, survival, and alterations in metabolism. The levels of HIF-1α subunit are increased in most solid tumors not only by low oxygen but also by growth f...
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The lipocalin mouse 24p3 has been implicated in diverse physiological processes, including apoptosis due to interleukin-3 (IL-3) deprivation and iron transport. Here we report cloning of the 24p3 cell-surface receptor (24p3R). Ectopic 24p3R expression confers on cells the ability to undergo either iron uptake or apoptosis, dependent upon the iron content of the ligand: Iron-loaded 24p3 increase...
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Department of Infection, Immunity, and Cardiovascular Disease and Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom; Medical Research Council/University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom; Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research...
متن کاملHIF-1α had Pivotal Effects on Downregulation of miR-210 Decreasing Viability and Inducing Apoptosis in Hypoxic Chondrocytes
Hypoxia-inducible factor 1-alpha (HIF-1 α ) and some microRNA (miRNAs) play pivotal roles in response to hypoxia-related physiologic and pathophysiologic responses. Up to date, the regulatory mechanisms of these molecules were largely unknown in chondrocytes. In this study, to study the mechanisms of degradation and homeostasis of chondrocytes, the effects of miRNAs and HIF-1 α on chondrocytes ...
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ژورنال
عنوان ژورنال: European Journal of Inflammation
سال: 2014
ISSN: 2058-7392,2058-7392
DOI: 10.1177/1721727x1401200106